![]() In one study, native T1 of remote myocardium decreased from baseline to 5 months after AMI, while in another study remote native T1 values remained constant. However, current data on native T1 and ECV of remote myocardium in AMI patients and their predictive role on left ventricular (LV) remodeling are conflicting. įindings from recent studies using T1 mapping suggest that tissue changes may also occur in remote myocardium after AMI, and that these changes are associated with adverse cardiac remodeling. Furthermore, post-contrast T1 mapping enables quantification of gadolinium (Gd)-based contrast accumulation within the interstitial space of the myocardium, and thereby provides a direct measure of the size of the extracellular volume (ECV). pre-contrast) T1 mapping now permits direct quantification of the absolute T1 relaxation times, and can therefore be used to detect and quantify myocardial edema, without the need for a reference region. In the past few years, several technological advances have occurred that improved the capability of CMR to characterize the myocardium. In vivo, pathological changes in myocardial tissue composition can be evaluated using cardiovascular magnetic resonance (CMR) imaging. ![]() There is increasing evidence indicating that also remote myocardium is subjected to pathophysiological changes after MI, although their severity and significance is still largely unknown. This does not alter our adherence to PLOS ONE policies on sharing data and materials.įollowing acute myocardial infarction (AMI), the infarcted myocardium undergoes a sequence of pathophysiological changes including myocardial necrosis, myocardial edema, microvascular injury, and subsequent healing with scar tissue formation. The funders had no role in the study design collection, analysis, and interpretation of data writing of the paper and/or decision to submit for publication. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: This work was supported in part by unrestricted research grants from Volcano Corporation ( ) and Biotronik ( )(NR). This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper.įunding: This work was supported in part by unrestricted research grants from Volcano Corporation ( ) and Biotronik ( )(NR). ![]() Received: MaAccepted: JPublished: June 23, 2017Ĭopyright: © 2017 Biesbroek et al. PLoS ONE 12(6):Įditor: Meijing Wang, Indiana University School of Medicine, UNITED STATES (2017) Changes in remote myocardial tissue after acute myocardial infarction and its relation to cardiac remodeling: A CMR T1 mapping study. Citation: Biesbroek PS, Amier RP, Teunissen PFA, Hofman MBM, Robbers LFHJ, van de Ven PM, et al.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |